Staufen 1 amplifies proapoptotic activation of the unfolded protein response
نویسندگان
چکیده
منابع مشابه
Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia.
BACKGROUND Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherapy. A novel approach to overcome chemotherapy resistance may be targeting the endoplasmic reticulum (ER). PATIENTS AND METHODS The involvement of the unfolded protein response (UPR) in the cell killing effect of xanthohumol (X) was examined in 18 patient samples. ...
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Maintenance of homeostasis of the endoplasmic reticulum (ER) ensures the balance between loading of nascent proteins and their secretion. Certain developmental conditions or environmental stressors affect protein folding causing ER stress. The resultant ER stress is mitigated by upregulating a set of stress-responsive genes in the nucleus modulating the mechanism of the unfolded protein respons...
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Cataract formation is a multifactorial disease, induced by a variety of stressors. The endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) is known to produce reactive oxygen species (ROS) leading to apoptosis. The present study aimed to investigate whether activation of the UPR occurs in human lenses, using human lens epithelial cell (HLEC) lines and lenses obtained from ...
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متن کاملThe unfolded protein response
Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations. The ER maintains a specialized oxidizing environment to aid ch...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2020
ISSN: 1350-9047,1476-5403
DOI: 10.1038/s41418-020-0553-9